Zonegran

Zonegran is a drug that is approved for use with other seizure medications to control partial seizures. It works by stopping seizure activity from starting and preventing it from spreading to other parts of the brain. The drug comes in capsule form and is generally taken once or twice a day. Common side effects of Zonegran include drowsiness, nausea, and headaches.

What Is Zonegran?

Zonegran® (zonisamide) is a prescription medication used to treat partial seizures, a specific type of epileptic seizure. Seizures are divided into two major categories: partial seizures (sometimes called focal seizures) and generalized seizures. Partial seizures occur in just one part of the brain, while generalized seizures affect both sides of the brain. Zonegran is approved to be used together with other seizure medications to control partial seizures.
 
(Click Zonegran Uses for more information, including possible off-label uses.)
 

Who Makes It?

Currently, Zonegran is made by Eisai, Inc.
 

How Does Zonegran Work?

Epilepsy is a brain disorder caused by recurring, brief changes in the brain's electrical system. These changes in brain activity can lead to a seizure (see Epilepsy Symptoms).
 
It is not known exactly how Zonegran works to prevent partial seizures in people with epilepsy. It may work by blocking sodium channels in the brain, which could decrease activity of nerve cells, preventing them from firing abnormally. The medication may also affect calcium in the brain. Evidence suggests that the medication works to stop seizure activity from starting and preventing it from spreading to other parts of the brain.
 

Effects of Zonegran

Three studies have shown that Zonegran is effective for treating partial seizures in adults whose seizures were not adequately controlled by other seizure medications. In these studies, people added either Zonegran or a placebo ("sugar pill") to the seizure medications they were already taking. Those who added the medication decreased their rates of partial seizures by up to 40.5 percent, compared to just 9 percent in those who added the placebo to their seizure medications.
 
 
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Zonegran Drug Information

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