Zonegran Drug Interactions
Zonegran drug interactions can occur when the seizure medication is taken with Luminal, Dilantin, or a number of other drugs. These interactions can lead to problems such as decreased drug levels in the blood. To learn more about the specific Zonegran drug interactions that apply to you, be sure to talk to your healthcare provider.
An Overview of Zonegran Drug InteractionsZonegran® (zonisamide) can potentially interact with other medications, particularly other seizure medications. Some of the medicines that may lead to Zonegran drug interactions include:
- Carbamazepine (Carbatrol®, Epitol®, Equetro™, Tegretol®)
- Carbonic anhydrase inhibitors, such as:
Zonegran Interactions ExplainedThe following sections explain in detail the potentially negative interactions that can occur when Zonegran is combined with any of the drugs listed above.
Carbamazepine can decrease the level of Zonegran in your blood, perhaps making it less effective. Your healthcare provider will recommend a higher Zonegran dosage if you are taking carbamazepine, and may lower your dosage if you stop taking carbamazepine.
Carbonic Anhydrase Inhibitors
Zonegran has carbonic anhydrase-inhibiting properties (carbonic anhydrase is an enzyme in the body). Taking Zonegran with other medications that have such properties may increase the risk of kidney stones and metabolic acidosis (a condition in which there is too much acid in the body).
Combining Zonegran with phenobarbital can decrease the level of Zonegran in your blood, possibly making it less effective. Your healthcare provider will recommend a higher Zonegran dosage if you are taking phenobarbital, and may lower your dosage if you stop taking phenobarbital.