Zonegran and Weight Loss

Are Zonegran and weight loss related? In clinical studies, up to 3 percent of people taking the medication to treat partial seizures experienced weight loss. While in some people, this side effect is not a problem, in children, it could become serious. If you are taking Zonegran and weight loss occurs, talk to your healthcare provider about ways to slow down or stop this side effect.

 

An Overview of Zonegran and Weight Loss

Zonegran® (zonisamide) is a prescription medication used to treat partial seizures, a certain type of epileptic seizure. Weight loss is one of the possible side effects that have been reported with the drug.
 

How Common Is Weight Loss With Zonegran?

In clinical studies, up to 3 percent of people taking Zonegran to treat partial seizures experienced weight loss, compared to 2 percent in a similar group of people not taking it. Appetite loss is also common, occurring in up to 13 percent of people taking Zonegran (compared to 6 percent of those not taking the drug). While some weight loss can be desirable for many people, weight loss in children or losing too much weight can be a problem.
 

Zonegran and Weight Loss: Final Thoughts

Weight loss is a common side effect of Zonegran. If you are noticing bothersome weight loss that is possibly due to Zonegran, talk with your healthcare provider. He or she may recommend ways to slow down or stop the weight loss. In more severe cases, your healthcare provider may recommend that you switch to a different epilepsy medication.
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;