Drug Interactions With Valproic Acid

Among the medications that can interact with valproic acid are chlorpromazine, ethosuximide, and nortriptyline. Drug interactions with valproic acid can alter the levels of some medicines in your blood. They may also increase your risk of side effects or make some medications less effective. Depending on the severity of these drug interactions with valproic acid, your healthcare provider may monitor you more closely or adjust your dosages.

Valproic Acid Drug Information

Drug Interactions With Valproic Acid: An Overview

Valproic acid (Depakene^®) can potentially interact with many other medications. Some of the medicines that may lead to valproic acid drug interactions include:

Amitriptyline (Elavil^®)
Aspirin
Carbamazepine (Epitol^®, Equetro™, Tegretol^®, Tegretol XR^®)
Chlorpromazine (Thorazine^®)
Clonazepam (Klonopin^®)
Diazepam (Valium^®)
Ethosuximide (Zarontin^®)
Felbamate (Felbatol^®)
Lamotrigine (Lamictal^®)
Meropenem (Merrem^®)
Nortriptyline (Pamelor^®)
Phenobarbital (Luminal^®)
Phenytoin (Dilantin^®, Phenytek^®)
Primidone (Mysoline^®)
Rifampin (Rifadin^®)
Tolbutamide (Orinase^®)
Topiramate (Topamax^®)
Warfarin (Coumadin^®, Jantoven^®)
Zidovudine (Retrovir^®).

Interactions With Valproic Acid Explained

The following sections explain in detail the potentially negative interactions that can occur when valproic acid is combined with any of the drugs listed above.

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