Drug Interactions With Valproic Acid

Phenytoin
Taking phenytoin with valproic acid can decrease the level of valproic acid in your blood, perhaps making it less effective. Taking these medications together may also raise the level of phenytoin in your blood, increasing your risk of side effects. If you are taking valproic acid and phenytoin together, your healthcare provider will monitor you more closely and adjust your doses of these medications, if necessary.
 
Primidone
Combining primidone with valproic acid can decrease the level of valproic acid in your blood, perhaps making it less effective. Taking these medications together may also raise the level of primidone in your blood, increasing your risk of side effects. If you are taking valproic acid along with primidone, your healthcare provider will monitor you more closely and adjust your doses of these medications if necessary.
 
Rifampin
Rifampin may decrease the level of valproic acid in your blood, perhaps making it less effective. If you are taking these drugs together, your healthcare provider may need to adjust your valproic acid dosage to prevent interactions from occurring.
 
Tolbutamide
Valproic acid can affect the level of tolbutamide in your blood. If you are taking these drugs together, your healthcare provider may need to adjust your tolbutamide dosage.
 
Topiramate
Combining topiramate with valproic acid can cause high levels of ammonia in your blood (hyperammonemia), which can be dangerous. If you are taking both of these medications, your healthcare provider should monitor you closely to make sure you are not developing this problem.
 
Warfarin
Taking warfarin and valproic acid together may increase your risk of bleeding. If you are taking both of these drugs, your healthcare provider may need to increase your warfarin dosage.
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Valproic Acid Drug Information

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