Trileptal and Pregnancy
In animal studies that looked at Trileptal and pregnancy, the drug caused problems such as miscarriages, birth defects, and growth problems. However, it is important to keep in mind that animals do not always respond to drugs in the same way that humans do. Trileptal may still be prescribed to a pregnant woman if her healthcare provider believes that the benefits outweigh the possible risks to her unborn child.
Is Trileptal Safe During Pregnancy?Trileptal® (oxcarbazepine) may not be safe for women who are pregnant. In previous animal studies involving Trileptal and pregnancy, the drug caused miscarriages, birth defects, and growth problems.
Trileptal and Pregnancy Category CThe U.S. Food and Drug Administration (FDA) uses a pregnancy category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans but do appear to cause harm to the fetus in animal studies. Also, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
When given to pregnant rats, Trileptal increased the risk of birth defects, including facial, skull, heart, and skeletal defects. Trileptal also increased the risk of miscarriages and low birth weight.
However, it is important to note that animals do not always respond to medicines in the same way that humans do. Therefore, a pregnancy Category C medicine may be given to a pregnant woman if her healthcare provider believes that its benefits to the pregnant woman outweigh any possible risks to her unborn child.
Due to changes that occur during pregnancy, it is predicted that levels of Trileptal in your blood may gradually decrease throughout pregnancy and may increase after giving birth. Therefore, if it is decided that you will take Trileptal during pregnancy, the level of Trileptal in your blood should be monitored carefully during pregnancy and through the postpartum period (the first six weeks after giving birth, at least) in order to maintain good seizure control.