Valproic Acid (Depakene) or Divalproex Sodium (Depakote, Depakote ER)
Taking
valproic acid or
divalproex sodium with
Topamax can decrease the level of both Topamax and valproic acid or
divalproex sodium in your blood, perhaps making the drugs less effective. Your healthcare provider may need to increase your dose of these medications. Also, taking these medications together can increase the level of ammonia in your blood, putting you at risk for brain problems.
Final Thoughts on Topamax Drug Interactions
It is possible that not every Topamax drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about drug interactions with Topamax that may apply to your situation.