Peganone Warnings and Precautions

If your healthcare provider prescribes Peganone to treat certain types of seizures, it is important that you discuss whether you have any type of blood disorder or liver disease. Other precautions for using Peganone safely include warnings of potential complications that may occur, such as drug interactions, allergic reactions, and other problems. Also, this drug may not be appropriate for women who are pregnant or nursing.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Peganone® (ethotoin) if you have:
  • Anemia or other blood disorders
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Peganone

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Seizure medications, including Peganone, may increase the risk for suicidal thoughts or behaviors (see Seizure Medications and Suicide). Please seek immediate medical attention if you have thoughts of suicide, a low mood, depression, or any unusual changes in your mood or behavior while taking this drug.
  • There have been reports of lymph node problems occurring in people taking Peganone. However, it is not known if Peganone is the cause of these problems. These problems include swollen and tender lymph nodes, which may be a sign of certain cancers or other complications. Usually, these problems go away when the drug is stopped, if indeed it is the cause.
  • Because Peganone can cause serious and even life-threatening skin rashes, tell your healthcare provider right away if you notice a rash. Most likely, you will need to stop Peganone either temporarily or permanently.
  • There have been cases of certain blood problems with medications like Peganone. Let your healthcare provider know immediately if you develop any signs of these problems, such as unusual bruising or bleeding or frequent or persistent infections.
  • Because Peganone can affect folic acid, it may increase the risk of megaloblastic anemia. Your healthcare provider may want to monitor you for this problem.
  • As with all seizure medications, Peganone should not be stopped suddenly.
  • Peganone is a pregnancy Category D medication. This means that it is probably not safe for use in pregnant women. Talk to your healthcare provider about the risks and benefits of taking the drug during pregnancy (see Peganone and Pregnancy).
  • Peganone passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Peganone and Breastfeeding).
Know the Signs - Concussion Safety

Peganone Medication Information

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