People who have a severe form of epilepsy known as Lennox-Gastaut syndrome may benefit from Onfi. This drug in meant to be used in combination with other seizure medications. In some cases, a healthcare provider may recommend "off-label," or unapproved, uses for Onfi, such as treating other types of seizures, alcohol withdrawal, and insomnia.
What Is Onfi Used For?Onfi™ (clobazam) is a prescription seizure medication. Specifically, it is approved to treat seizures due to Lennox-Gastaut syndrome (LGS). It is approved to be used along with other seizure medications.
Lennox-Gastaut syndrome is a severe form of epilepsy. Epilepsy is a brain condition that occurs when there are sudden, brief changes in how the brain's electrical system works. This change in brain activity can lead to a seizure (see Epilepsy Symptoms). Depending on which part of the brain is affected, a seizure may cause problems with:
- A person's consciousness
- Body movements
- Senses (taste, touch, smell, vision, or hearing).
Lennox-Gastaut syndrome usually begins early in children, typically before four years of age. This type of epilepsy is often accompanied by developmental delays and other problems. The seizures due to Lennox-Gastaut syndrome can be particularly difficult to treat, and many people need to take several medications.
Onfi is approved for use in combination with other seizure medications to treat Lennox-Gastaut syndrome seizures and is approved for use in adults and children as young as two years old.
As is typical with new seizure medications, Onfi is not approved to be used alone, as it has not been adequately studied for such use. In studies, people were given either Onfi or a placebo (a "sugar pill" that does not contain any active ingredients) to take in addition to their usual seizure medications, because it would be unethical to give a person with Lennox-Gastaut syndrome just a placebo without the other medications.