Epilepsy Home > Side Effects of Primidone

While most people tolerate primidone well, side effects can still occur with this medication. Common side effects of primidone include coordination problems and spinning sensations (vertigo). In most cases, the side effects of primidone are minor and are easily treated by you or your healthcare provider. However, some of the more serious side effects of the drug (such as unusual bleeding or seizures that are becoming worse) may require immediate medical attention.

An Introduction to Side Effects of Primidone

As with any medicine, side effects are possible with primidone (Mysoline®). However, not everyone who takes the medication will experience side effects. In fact, most people tolerate primidone quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with primidone. Your healthcare provider can discuss a more complete list of primidone side effects with you.)

Common Side Effects of Primidone

Primidone is an older seizure medication, approved many years ago. With newer medications, side effects are carefully documented, and the exact percentage of people that develop each side effect is known. With older medications, like primidone, the information on side effects is less specific, and exact percentages are not reported.
The most common side effects of primidone (especially in people first starting the medication) include:
  • Coordination problems
  • A spinning sensation (vertigo).
In general, the above side effects usually improve with time. Other common side effects include:
  • Nausea, vomiting, or appetite loss
  • Fatigue
  • Irritability
  • Impotence (also known as erectile dysfunction or ED)
  • Double vision or unusual eye movements
  • Drowsiness.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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