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Primidone Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when primidone is combined with any of the drugs listed above.
 
Alcohol
Combining alcohol with primidone can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. It is best to avoid alcohol while taking primidone.
 
Anesthetics
Combining anesthetics with primidone can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. Make sure your healthcare providers know you are taking primidone before you undergo any surgical procedure.
 
Antidepressant Medications
Combining an antidepressant with primidone can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. Make sure to talk to your healthcare provider before taking primidone with an antidepressant, as you may need to be monitored more closely.
 
Barbiturates
Combining a barbiturate with primidone can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. Make sure to talk to your healthcare provider before taking primidone with a barbiturate.
 
Benzodiazepines
Combining primidone with benzodiazepines can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may occur. Make sure to talk to your healthcare provider before taking primidone with a benzodiazepine.
 
Certain Antifungal Medications
Taking certain antifungal medications with primidone can decrease the level of the antifungal medication in your blood, perhaps making it less effective. Talk to your healthcare provider before taking these medications together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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