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Onfi is a medicine prescribed to treat seizures caused by Lennox-Gastaut syndrome. It is approved for adults and children as young as two years of age, and is meant for use in combination with other seizure medications. This medicine comes as a tablet or a liquid that is taken once or twice a day. Possible side effects may include drowsiness, fever, and aggression.

What Is Onfi?

Onfi™ (clobazam) is a prescription medication approved to treat seizures in people with Lennox-Gastaut syndrome (LGS). It is approved for use only along with other seizure medications and can be used in adults and children as young as two years old.
(Click Onfi Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medicine?

Onfi is made by Catalent Pharma Solutions, LLC, for Lundbeck, Inc.

How Does Onfi Work?

Onfi belongs to a group of medications called benzodiazepines. Benzodiazepines have various effects on the body, such as:
  • Reducing anxiety
  • Causing sleepiness
  • Relaxing muscles
  • Stopping seizures
  • Impairing short-term memory.
All benzodiazepines can have these effects to some degree, depending on the specific benzodiazepine that is being taken. They work in the brain by enhancing the effects of gamma-aminobutyric acid (GABA), a brain chemical that is naturally calming. GABA can slow down or stop certain nerve signals in the brain. This is why Onfi and other benzodiazepines are known as mild tranquilizers, sedatives, or central nervous system depressants (CNS depressants).

Clinical Effects

This medication has been thoroughly evaluated in clinical studies. These studies looked at Onfi in people with Lennox-Gastaut syndrome whose seizures were not adequately controlled with their current medications.
In one study, adding Onfi significantly reduced seizure frequency by up to 68.3 percent (depending on the dose), compared to only 12.1 percent for those who were given a placebo (a "sugar pill" that does not contain any active ingredients) in addition to their regular seizure medications.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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