Lamictal XR is a seizure medication that can be used by people who are at least 13 years old. It comes in the form of a tablet that is taken once a day, and is only approved for use when taken with other seizure medications. The medicine is thought to work by affecting the electrical system in the brain. Possible side effects include dizziness, nausea, and fatigue.
Seizures are the result of brief changes in how the brain's electrical system works. It is not known exactly how Lamictal XR works to treat seizures. Studies suggest that the medication may work by affecting sodium channels in the brain, preventing the abnormal activity from "firing" and spreading to other parts of the brain. This action helps control seizures.
Clinical Effects of Lamictal XR
This medicine has been thoroughly evaluated in clinical studies. These studies evaluated Lamictal XR in people with partial-onset seizures whose seizures were not adequately controlled with their current medications.
In one study, adding Lamictal XR significantly reduced seizure frequency by up to 47 percent, compared to only 25 percent who were given a placebo (a "sugar pill" with no active ingredients) in addition to their regular seizure medications.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Lamictal XR [package insert]. Research Triangle Park, NC: GlaxoSmithKline;2012 August.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed October 6, 2009.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed October 6, 2009.
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