Epilepsy Home > Fycompa

If you have certain types of partial seizures, your healthcare provider may prescribe Fycompa. This drug is specifically designed for use in adults and children as young as 12 years old. It comes as a tablet that is taken once a day at bedtime. Dizziness, sleepiness, and irritability are some of the possible side effects.


What Is Fycompa?

Fycompa™ (perampanel) is a prescription anti-seizure medication. It is approved for use with other anti-seizure medicines to treat partial-onset seizures in adults and children as young as 12 years old with epilepsy.
Partial seizures are a type of seizure that occurs in just one area of the brain. In some cases, partial seizures can spread and turn into seizures that affect the entire brain. This is known as "secondary generalization." Fycompa is approved to treat partial-onset seizures that remain in one area of the brain and partial-onset seizures with secondary generalization.
(Click Fycompa Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Fycompa is made by Eisai, Inc.

Clinical Effects

In clinical studies, Fycompa was shown to reduce the frequency of seizures in people with epilepsy whose seizures were inadequately controlled on one to three other anti-seizure medications. In these studies, people given Fycompa in addition to their other seizure medicines had a reduction in their seizure frequency by 4.4 percent to 20.2 percent more than those given a placebo (a "sugar pill" with no active ingredients). In general, higher doses resulted in greater seizure reduction than lower doses.

How Does Fycompa Work?

Seizures are the result of brief abnormal activity in the brain's electrical system. It is not exactly known how Fycompa works to treat seizures. The drug is thought to work by blocking the action of a chemical in the brain known as glutamate. Glutamate is the main excitatory chemical in the brain -- that is, it can excite brain neurons, causing them to fire rapidly.
By blocking the action of glutamate, Fycompa stops this rapid firing of neurons and prevents the spread of abnormal electrical activity throughout the brain. This action is thought to prevent seizures from occurring.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation




Related Channels

eMedTV Links
Copyright © 2006-2019 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.