Epilepsy Home > Dilantin Drug Interactions

Disulfiram 
Disulfiram can raise the amount of Dilantin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of Dilantin in your blood and adjust your dose as necessary.
 
Doxycycline
Dilantin may make doxycycline less effective. If you are taking these drugs together, your healthcare provider may need to increase your doxycycline dosage.
 
Estrogen Medications
Estrogens can raise the amount of Dilantin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of Dilantin in your blood and adjust your dose as necessary. Also, Dilantin can make estrogens less effective, which is especially important for estrogens in oral contraceptives (birth control pills).
 
Folic Acid
Folic acid may decrease the level of Dilantin in your blood. Check with your healthcare provider before combining Dilantin with folic acid.
 
Fluoxetine
Fluoxetine can raise the amount of Dilantin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of Dilantin in your blood and adjust your dose as necessary.
 
Fluvastatin
Fluvastatin can raise the amount of Dilantin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of Dilantin in your blood and adjust your dose as necessary. In addition, Dilantin may decrease fluvastatin levels, perhaps making it less effective.
 
Fluvoxamine
Fluvoxamine can raise the amount of Dilantin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of Dilantin in your blood and adjust your dose as necessary.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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