Epilepsy Home > Dilantin Drug Interactions

Chemotherapy Medications
Many chemotherapy medications, including both oral and IV ones, interact with Dilantin. Some increase the level of Dilantin, while others decrease Dilantin levels. In addition, Dilantin may make certain chemotherapy medications less effective. Always check with your healthcare provider before combining Dilantin with any chemotherapy drugs.
 
Chloramphenicol
Chloramphenicol can raise the level of Dilantin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of Dilantin in your blood and adjust your dose as necessary.
 
Chlordiazepoxide 
Chlordiazepoxide can raise the level of Dilantin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of Dilantin in your blood and adjust your dose as necessary.
 
Corticosteroids
Dilantin may make corticosteroids less effective. If you are taking these drugs together, your healthcare provider may need to increase your corticosteroid dosage.
 
Cyclosporine
Dilantin may make cyclosporine less effective. If you are taking these drugs together, your healthcare provider may need to monitor your cyclosporine levels and perhaps increase your dosage.
 
Delavirdine
Dilantin and delavirdine should not be taken together, as combining them may make delavirdine less effective and may increase the risk of developing resistance to delavirdine or other similar HIV drugs.
 
Diazepam 
Diazepam can raise the amount of Dilantin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of Dilantin in your blood and adjust your dose as necessary.
 
Digoxin 
Dilantin may make digoxin less effective. If you are taking these drugs together, your healthcare provider may need to increase your digoxin dosage.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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