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Interactions With Dilantin Explained

The following sections explain in detail the potentially negative interactions that can occur when Dilantin is combined with any of the drugs listed above.
Alcohol can interfere with the way your body handles Dilantin. Chronic alcohol intake can decrease the level of Dilantin in your blood, while short-term intake of a large amount of alcohol can increase the level of Dilantin in your blood. Be sure to discuss your drinking habits with your healthcare provider (see Dilantin and Alcohol for more information).
Amiodarone can increase the amount of Dilantin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of Dilantin in your blood and adjust your dose as necessary.
Dilantin may decrease the level of atorvastatin in your bloodstream, perhaps making it less effective. While this is not a particularly dangerous interaction, your healthcare provider may want to monitor your cholesterol levels to make sure atorvastatin remains effective for you.
Calcium-Containing Products
Calcium can interfere with the absorption of Dilantin into your bloodstream. Try not to take Dilantin and calcium products at the same time of the day.
Certain Antifungal Medications
Combining Dilantin with certain antifungal medications may increase the level of Dilantin in your bloodstream and may decrease the level of the antifungal. Check with your healthcare provider before taking Dilantin with an antifungal.
Certain Seizure Medications
Some seizure medications may increase the level of Dilantin in the blood, while others may decrease Dilantin levels. Some can interact with Dilantin unpredictably. In addition, Dilantin may make other seizure medications less effective. Always double-check with your healthcare provider before combining any seizure medications with Dilantin.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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