Epilepsy Home > Drug Interactions With Diazepam

Grapefruit Juice
Grapefruit juice can raise the level of diazepam in your blood, increasing your risk of diazepam side effects. It is best to avoid grapefruit juice while taking diazepam. If your healthcare provider decides that it is okay for you to drink grapefruit juice during treatment with diazepam, you should do so consistently and in moderation.
 
Narcotics or Opiates
Combining an opiate or narcotic with diazepam can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk with your healthcare provider before taking diazepam with an opiate or narcotic.
 
Other Benzodiazepines
Combining diazepam with other benzodiazepines can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk with your healthcare provider before taking diazepam with another benzodiazepine.
 
Probenecid
Probenecid can raise the level of diazepam in your blood, increasing your risk of diazepam side effects. Typically, your healthcare provider will need to lower your diazepam dosage (usually by 50 percent) if you are taking diazepam along with probenecid.
 
Seizure Medications
Combining a seizure medication with diazepam can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk with your healthcare provider before taking diazepam with a seizure medication.
 
Sleep Medications
Combining a sleep medication with diazepam can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk with your healthcare provider before taking diazepam with a sleep medication.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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