If you have Lennox-Gastaut syndrome, you may benefit from Banzel. This prescription medication is approved for use in combination with other seizure medications to control seizures in adults and children with this syndrome. The drug is available in tablet form and as an oral suspension, and is typically taken twice a day. Some of the common side effects of Banzel include headaches, nausea, and drowsiness.
What Is Banzel?
Banzel™ (rufinamide) is a prescription medication approved to treat seizures in people with Lennox-Gastaut syndrome (LGS). It is only approved for use in combination with other seizure medications and can be used in adults and children as young as four years old.
Seizures are the result of brief changes in how the brain's electrical system works. It is not known exactly how Banzel works to treat seizures. Studies suggest that it may work by affecting sodium channels in the brain, preventing the abnormal activity from spreading to other parts. In particular, this medication seems to keep the sodium channels in an inactive state for a longer period of time, which helps control seizures.
This medication has been thoroughly evaluated in clinical studies. These studies evaluated Banzel in people with Lennox-Gastaut syndrome whose seizures were not adequately controlled with their current medications. Adding this medication significantly reduced seizure frequency by 32.7 percent, compared to only 11.7 percent who were given a placebo (a "sugar pill" that does not contain any active ingredients) in addition to their regular seizure medications.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Banzel [package insert]. Woodcliff Lake, NJ: Eisai, Inc.; 2011 March.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed May 27, 2010.
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