Treatment for this condition includes antiepileptic medications such as valproate, lamotrigine, felbamate, rufinamide, or topiramate. There is usually no single antiepileptic medication that will control seizures. Children who improve initially may later show tolerance to a drug or have uncontrollable seizures.
The prognosis for individuals with Lennox-Gastaut syndrome varies. There is no cure for the disorder. Complete recovery, including freedom from seizures and normal development, is very unusual for people with Lennox-Gastaut syndrome.