Lamictal Drug Interactions

Oral Contraceptives or Hormone Replacement Therapy
Oral contraceptives (birth control pills) or hormone replacement therapy (HRT) can decrease the level of Lamictal in your blood, perhaps making it less effective. This is especially problematic for cyclical birth control pills or hormone replacement therapies that have a week of inactive pills to allow you to have your period, as your Lamictal levels will increase during the inactive pill week.
 
Talk to your healthcare provider about other birth control options; a non-hormonal method (such as condoms) may be best for your situation.
 
Phenobarbital
Phenobarbital can decrease the level of Lamictal in your blood, possibly making it less effective. Your healthcare provider may recommend a higher Lamictal dose if you are taking phenobarbital and may recommend decreasing this dose if you stop taking phenobarbital.
 
Phenytoin
Phenytoin may decrease the level of Lamictal in your blood, perhaps making it less effective. Your healthcare provider may recommend a higher dose of Lamictal if you are taking phenytoin and may recommend decreasing this dose if you stop taking phenytoin.
 
Primidone
Primidone may decrease the level of Lamictal in your blood, perhaps making it less effective. Your healthcare provider may recommend a higher dose of Lamictal if you are taking primidone and may recommend decreasing this dose if you stop taking primidone.
 
Rifampin
Rifampin may decrease the level of Lamictal in your blood, perhaps making it less effective. Your healthcare provider may recommend a higher Lamictal dose if you are taking rifampin and may recommend decreasing the dose if you stop taking rifampin.
 

Final Thoughts on Lamictal Drug Interactions

It is possible that not all Lamictal drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions that may apply to you.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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