Lamictal and Pregnancy

In animal studies on Lamictal and pregnancy, large doses of the drug caused low fetal weight and slow bone development. It also decreases folic acid in the body, which could increase the risk of birth defects. However, it may be best for you to continue taking the drug, so if you are taking Lamictal and pregnancy occurs, talk to your healthcare provider.

Is Lamictal Safe During Pregnancy?

Lamictal® (lamotrigine) may not be safe for women who are pregnant, although the full risks are not known. In studies that looked at the effects of Lamictal during pregnancy, the drug caused a few problems.

Lamictal and Pregnancy Category C

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans but that do appear to cause harm to the fetus in animal studies. Also, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
In animal studies, large doses of Lamictal given to pregnant mice and rats caused low fetal weight and slow bone development. Animal studies also suggest that the drug may increase the risk of miscarriage in rats. In addition, Lamictal decreases folic acid in the body. Since folic acid helps prevent birth defects, it might be expected that the drug would increase this risk. However, animal studies have not shown this to be the case.
If you and your healthcare provider decide that it is best for you to continue taking Lamictal, your healthcare provider may suggest a higher-than-usual dose of folic acid, as this may help protect the fetus.
If you would like, your healthcare provider can submit information about you and your pregnancy to the Lamictal Pregnancy Exposure Registry, a service that collects information on the use of Lamictal during pregnancy. Your information would be used to help determine if the drug causes problems in pregnant women. Talk to your healthcare provider if you would like to be included in this program.
Pregnancy and Pain

Lamictal Drug Information

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