Lamictal XR Drug Interactions

Lamictal XR can react with a number of products, including phenobarbital, carbamazepine, and hormonal contraceptives. Drug interactions with Lamictal XR can lead to problems such as decreased effectiveness of your medications and increased risk of side effects. Before starting treatment, make sure your healthcare provider is aware of all other medications you are taking.

Lamictal XR Medication Information

An Overview of Interactions With Lamictal XR

Lamictal^® XR™ (extended-release lamotrigine) can potentially react with a number of other medications. Some of the medicines that may lead to Lamictal XR drug interactions include:

Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
Hormonal contraceptives (such as birth control pills) or hormone replacement therapy (HRT)
Phenobarbital (Luminal^®)
Phenytoin (Dilantin^®, Phenytek^®)
Primidone (Mysoline^®)
Rifampin (Rifadin^®)
Valproate medications, such as:
- Delayed release valproic acid (Stavzor^®)
- Divalproex (Depakote^®)
- Divalproex ER (Depakote^® ER)
- Valproic acid (Depakene^®).

Lamictal XR Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Lamictal XR is combined with any of the medications listed above.

Carbamazepine

Carbamazepine can decrease the level of Lamictal XR in your blood, perhaps making it less effective. Your healthcare provider may recommend a higher dose of Lamictal XR if you are taking carbamazepine. In addition, using this medication may increase your risk of certain Lamictal XR side effects, such as dizziness, vision problems, or coordination problems.

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