Keppra Warnings and Precautions

Understanding Keppra warnings and precautions can help ensure a safe treatment process. Tell your healthcare provider if you have anemia, kidney disease, or any allergies before taking Keppra. You should not take Keppra if you are allergic to the medication or any of its ingredients. Keppra warnings and precautions also relate to the safety of taking the medication when pregnant or breastfeeding and the risk of suddenly stopping the medication.

Keppra: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Keppra® (levetiracetam) if you have:
  • Anemia or any other blood disorder
  • Kidney disease, including kidney failure (renal failure)
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Keppra Warnings and Precautions

Some warnings and precautions to be aware of prior to taking Keppra include the following:
  • Keppra can cause drowsiness and problems with coordination. Be sure to tell your healthcare provider if you develop any of these Keppra side effects, especially if they are severe and do not improve with time. Also, make sure to see how Keppra affects you before driving or operating any machinery.
  • Keppra can cause behavioral or emotional changes. Let your healthcare provider know if you develop bothersome or disturbing changes, such as depression, personality changes, anxiety, or hallucinations.
  • As with all seizure medications, Keppra should not be suddenly stopped (see Keppra Withdrawal).
  • In studies, Keppra caused minor changes in blood counts, especially changes in red blood cells and a certain type of white blood cells called neutrophils. This is not expected to cause problems in most people, unless you already have a problem with anemia or other blood disorders.
  • The kidneys help remove Keppra from your body. If you have kidney disease, your healthcare provider may suggest a lower Keppra dosage.
  • Keppra is considered a pregnancy Category C medication. This means that it may not be safe for pregnant women. Talk to your healthcare provider about the risks and benefits of taking the drug during pregnancy (see Keppra and Pregnancy).
  • Keppra passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Keppra and Breastfeeding).


  • Early evidence suggests that seizure medications, including Keppra, may increase the risk of suicidal thoughts or behaviors (see Seizure Medications and Suicide for more information)
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Keppra Medication Information

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