Dilantin Toxicity

Serious toxicity can potentially occur with the use of Dilantin. Toxicity is more likely to occur in newborns, elderly people, and people with kidney or liver disease. It is also more likely to happen when Dilantin doses are increased or when other medications are started or stopped (due to drug interactions). Common symptoms of Dilantin toxicity may include dizziness, lethargy, drowsiness, and rapid eye movements.

 

Can Dilantin Be Toxic?

Dilantin® (phenytoin) is a prescription medication used to treat certain types of seizures in people with epilepsy. As with many medications, Dilantin can cause serious toxicity. Dilantin toxicity can occur as a result of taking a daily dose of the drug that is too high or a single Dilantin overdose (either intentional or accidental). It is important for people who take the medication to be aware of the symptoms of toxicity.
 

Dilantin Toxicity Symptoms

The symptoms of Dilantin toxicity can vary, depending on the level of Dilantin in the blood. Some of the most common signs include:
 
  • Rapid eye movements
  • Difficulty speaking or slurred speech
  • Lethargy
  • Problems with coordination or balance
  • Dizziness
  • Drowsiness
  • Unusual body movements or shakiness.
     
Some other possible symptoms include:
 
  • Confusion
  • Hallucinations
  • Coma
  • Seizures
  • Double vision
  • Nausea and vomiting
  • Difficulty swallowing
  • Irritability or agitation
  • Low blood pressure
  • Gum tenderness.
     
Loss of life due to Dilantin toxicity is possible, but not common.
 
(Dilantin Toxicity Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;