Dilantin Drug Interactions

A number of medicines can potentially cause interactions with Dilantin. Drug interactions may occur if Dilantin is taken together with corticosteroids, fluoxetine, salicylates, or cimetidine, among other medications. Dilantin drug interactions can decrease the effectiveness of some medicines and increase your risk of developing side effects.

 

An Overview of Dilantin Drug Interactions

Dilantin® (phenytoin) can potentially interact with many other medications. Some of these medicines that may lead to Dilantin interactions include:
 

 

 

 

 

  • Quinidine
  • Reserpine
  • Rifampin (Rifadin®)
  • Salicylates, such as aspirin (Ecotrin®, Bayer®, Anacin®), choline magnesium trisalicylate (Trilisate®), diflunisal (Dolobid®), and salsalate (Salflex®, Disalcid®, Amigesic®)
  • Sucralfate (Carafate®)
  • Sulfonamides ("sulfa drugs"), including sulfadiazine, sulfadoxine (Fansidar®), sulfamethoxazole (Bactrim®, Septra®), and sulfisoxazole (Gantrisin®)
  • Ticlopidine (Ticlid®)
  • Theophylline
  • Tolbutamide (Orinase®)
  • Trazodone (Desyrel®)
  • Valproic acid (Depakene®) or divalproex sodium (Depakote®, Depakote ER®)
  • Warfarin (Coumadin®, Jantoven®).
     
(Dilantin Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;