Dilantin Drug Interactions (Cont.)

 
Theophylline
Dilantin can make theophylline less effective. If you are taking these drugs together, your healthcare provider may need to increase your theophylline dosage.
 
Tolbutamide (Orinase)
Tolbutamide can increase the amount of Dilantin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of Dilantin in your blood and adjust your dose as necessary.
 
Trazodone (Desyrel)
Trazodone can increase the amount of Dilantin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of Dilantin in your blood and adjust your dose as necessary.
 
Valproic Acid (Depakene) or Divalproex Sodium (Depakote, Depakote ER)
Valproic acid and divalproex sodium interact with Dilantin unpredictably, either increasing or decreasing the amount of Dilantin in your blood. Your healthcare provider should measure your Dilantin level and adjust your dose as necessary.
 
Warfarin (Coumadin, Jantoven)
Dilantin may make warfarin less effective. If you are taking these drugs together, your healthcare provider may need to increase your warfarin dosage.
 

Final Thoughts on Dilantin Drug Interactions

It is possible that not all Dilantin drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions with Dilantin that may apply to you. Because so many medications interact with Dilantin, it is a good idea to let your healthcare provider know anytime you start, stop, or change your dose of any medication (including non-prescription medications) during treatment with Dilantin.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;