Depakote ER Side Effects

Serious Side Effects

Some Depakote ER side effects, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include, but are not limited to:


    • Severe abdominal pain (or stomach pain)
    • Nausea and vomiting
    • Loss of appetite


  • Worsening of seizures
  • Low body temperature (below 95 degrees F), known as hypothermia
  • Unexplained bruising or bleeding
  • Signs of an allergic reaction, including unexplained rash, hives, itching, and unexplained swelling
  • Suicidal thinking or behavior (see Seizure Medications and Suicide).

Less Common Depakote ER Side Effects

There are other possible side effects that occur less frequently. These side effects occur in less than 5 percent of people. For these side effects, however, it is difficult to tell whether they are actually caused by Depakote ER or other factors.
Some of these less common but possible Depakote ER side effects include:
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Depakote ER Drug Information

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