Depakote ER Drug Interactions (Cont.)

 
Ethosuximide (Zarontin)
Depakote ER can raise the amount of ethosuximide in your blood, increasing your risk of side effects. Your healthcare provider may need lower your ethosuximide dosage.
 
Felbamate (Felbatol)
Felbamate can raise the amount of Depakote ER in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of Depakote ER in your blood and adjust your dose as necessary.
 
Lamotrigine (Lamictal)
Depakote ER can raise the amount of lamotrigine in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your lamotrigine dosage.
 
Nortriptyline (Pamelor)
Depakote ER can increase the level of nortriptyline in your blood, increasing your risk of nortriptyline side effects. Your healthcare provider may need to decrease your nortriptyline dosage.
 
Phenobarbital (Luminal)
Taking phenobarbital with Depakote ER can decrease the level of Depakote ER in your blood, perhaps making it less effective. Taking these medications together may also raise the level of phenobarbital in your blood, increasing your risk of side effects. Your healthcare provider will monitor you more closely and adjust your doses of these medications if necessary.
 
Phenytoin (Dilantin, Phenytek)
Taking phenytoin with Depakote ER can decrease the level of Depakote ER in your blood, perhaps making it less effective. Taking these medications together may also raise the level of phenytoin in your blood, increasing your risk of side effects. Your healthcare provider will monitor you more closely and adjust your doses of these medications if necessary.
 
Primidone (Mysoline)
Taking primidone with Depakote ER can decrease the level of Depakote ER in your blood, perhaps making it less effective. Taking these medications together may also raise the level of primidone in your blood, increasing your risk of side effects. Your healthcare provider will monitor you more closely and adjust your doses of these medications if necessary.
(Depakote ER Drug Interactions Continued: Page 4)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;